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Microneedle is a more common physical strategy to enhance delivery of anti-wrinkle peptides so that the delivery of GHK-Cu, 24 Pal-KTTKS, melanostatin, 39 GQPR, acetyl hexapeptide-3 and VGVAPG (valine-glycine-valine-alanine-proline-glycine) 40 has been investigated after microneedle treatment
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Two hours post infection, p-AMPK levels were declined and Sirt1 protein remained non-induced in contrast to p53 levels, which increased demonstrating a pro-apoptotic state in neurons (Martin et al., 2014b)