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KBD is characterized by the degeneration of articular cartilage between joints (osteoarthritis) that can result in joint deformities and dwarfism in the most severe forms of the disease

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Treatment with a novel selective small molecule inhibitor of G6PD (G6PDi-1) prior to T cell restimulation consequently blocked the production of proatherogenic cytokines TNFɑ and IFNγ by CD8 + T cells as well as IL-2 and TNFɑ by CD4 + T cells