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Supplementary material The Supplementary Material for this article can be found online at: References Chen J., Wang M., Joyce A., DeFranco D., Kavosi M., Xu X., et al

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For a compound to progress from its current status to FDA approval, it would need to complete IND-enabling studies (including formal toxicology and GMP manufacturing), a Phase 1 safety trial in humans, Phase 2 efficacy and dose-finding trials, and Phase 3 confirmatory trials — a process that typically takes 8 to 15 years and costs hundreds of millions of dollars with no guarantee of success