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Second, the crosstalk between p53 and other ferroptosis-regulating pathways (e.g., iron metabolism, lipid peroxidation machinery, and mitochondrial signaling) is poorly characterized

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Mia40 itself is kept oxidized by the FAD-dependent sulfhydryl oxidase Erv1 [66], which transfers electrons onto molecular oxygen either directly or via cytochrome c [173,174] (Fig