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It also contains a deletion of 70 amino acid residues from the C-terminus, a region that is highly flexible and that contains an immunodominant linear epitope that is strongly targeted by non-nAbs in convalescent COVID-19 plasma
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Key mechanisms include: Activation of neurons in the area postrema and nucleus tractus solitarius in the brainstem Enhanced satiety signaling through distinct pathways from GLP-1 mechanisms Slowed gastric emptying via calcitonin receptor-mediated effects Reduced food reward signaling and decreased “food noise” through central appetite centers Studies in knockout mouse models confirmed that cagrilintide’s weight loss effects depend specifically on AMY1R and AMY3R presence, demonstrating receptor-specific mechanisms⁴
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