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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brain’s immune system, including microglia and astrocytes ( A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brain’s antioxidant defenses, one such defense being glutathione (GSH) ( GSH is the most abundant endogenous antioxidant in the brain and plays an important role in counteracting oxidative stress ( This review focuses specifically on how GSH affects immune cells in the brain, specifically CNS-resident glial cells such as microglia and astrocytes
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