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Regulatory status has also drawn scrutiny, and it can vary by jurisdiction and context

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Two notable scaffolds have garnered attention for their significant thermodynamic stability and kinetic inertness in systemic circulation: 7.6.1.1 Tetraaza macrocycles (e.g., cyclams) Tetraaza macrocycles, including cyclams, function as essential ligands that stabilize transition metals such as Ni 2+ or Cu 2+