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The 50 cases presented in Gerson’s 1958 book (US DoH 1987)were also reviewed by the NCI in 1959, however, it was concluded that the case histories were not presented in sufficient detail (for instance, verification of the tumour, previous treatment history) to be able to evaluate the clinical benefit of the therapy (Gerson 1999)

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Collectively, the non-canonical peptide sequences, i.e., not templated in the genome, resulting from these processes will be referred to as alternative antigens (also termed “neo-antigens” in the literature)