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Figure 7 Autonomic dysfunction, vasoconstriction, and hypoxia Many ME/CFS patients have a unique cardiovascular situation (58) and changes indicative of autonomic dysfunction (329–331)

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Lipid-based DDSs (LBDDSs) utilize phospholipid bilayer architectures [e.g., liposomes, ethosomes, and solid lipid nanoparticles (SLNs)] to achieve localized drug enrichment in joint cavities or inflammatory foci, with reduced immunogenicity due to biomimetic membrane properties (Seo et al., 2023)