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In diet-induced obese mouse models, white adipose tissue mass ~35% below control was recorded following NNMT inhibition with 5-Amino-1MQ, with food intake unchanged - pointing to energy expenditure rather than appetite

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Quercetin, a potent ingredient of GSE, has been reported to promote apoptosis by lowering the expression levels of antiapoptotic proteins and increasing the expression levels of proapoptotic proteins, while also inhibiting tumor cell proliferation and disrupting cell cycle progression in A375SM melanoma cells, A2780S ovarian cancer cells, HL-60 AML cells, and gastric cancer cells (65, 68, 98–101)