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This group may include: Vegetarians and vegans Individuals with gastrointestinal disorders that hinder absorption, such as Crohn's disease or celiac disease Older adults, as absorption tends to decrease with age People who have undergone weight loss surgeries If you identify with any of these categories or have experienced symptoms of deficiency, consulting with a healthcare professional about vitamin B12 shots may be a wise decision

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The 22.7% number is the trial-product estimand (what happens if participants stay on treatment as intended)