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These nonantimicrobial sulfonamides do not undergo metabolism to the N 4 -hydroxylated metabolite associated with SJS and will not bind to IgE at the N 1 position and, therefore, are unlikely to cause cross-reactivity, even in patients who have experienced type 1 hypersensitivity or serious non-type-1 hypersensitivity reactions to sulfonamide antimicrobial agents

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I., Malmström, V., Schett, G