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A well-characterized example of this mechanism is the Keap1–Nrf2 signaling axis, illustrated in Fig

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As a specific class of ROS, excessive lipid peroxidation can disrupt plasma membrane integrity and further trigger multiple cell death modalities, including ferroptosis, apoptosis, necroptosis, pyroptosis, parthanatos, autophagy, cuproptosis, lysosomal‐dependent cell death, and NETosis [114]