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For patients, this means the practical comparison is: Tirzepatide alone: ~22.5% weight loss, FDA-approved, available now CagriSema: ~22.7% weight loss, investigational, possibly available 2026-2027 if approved Cagrilintide alone: ~10% weight loss, unlikely commercial path Cagrilintide monotherapy is unlikely to be commercially successful as a standalone obesity drug given the much stronger options available

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